PGC-1α: a master gene that is hard to master

What is a Master Regulator?

Copyright: © 2013 Chan SSK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The term “master regulator” or “master regulatory gene” was first coined by Susumu Ohno over 30 years ago for a “gene that occ...

Myocardin is a master regulator of smooth muscle gene expression.

Virtually all smooth muscle genes analyzed to date contain two or more essential binding sites for serum response factor (SRF) in their control regions. Because SRF is expressed in a wide range of cell types, it alone cannot account for smooth muscle-specific gene expression. We show that myocardin, a cardiac muscle- and smooth muscle-specific transcriptional coactivator of SRF, can activate sm...

Is angiotensin I-converting enzyme a "master" disease gene?

Clustering of diseases has been appreciated by health insurers and epidemiologists for some time. Co-morbidity suggests shared pathways of disease. It is by now well agreed that common diseases have a strong genetic component. Here we present evidence that the angiotensin I-converting enzyme (ACE) deletion/deletion (D/D) genotype is associated with a large number of common adult diseases, inclu...

Who is the Master?

There has been debates for years on how to rate chess players living and playing at different periods (see Keene and Divinsky (1989)). Some attempts were made to rank them not on the results of games played, but on the moves played in these games, evaluating these moves with computer programs. However, the previous attempts were subject to different criticisms, regarding the strengths of the pr...

Gene Fragment Programming Master thesis